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Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion - Nature Microbiology

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Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion - Nature Microbiology

Argonaute (Ago) proteins are found in all three domains of life. The so-called long Agos are composed of four major domains (N, PAZ, MID and PIWI) and contribute to RNA silencing in eukaryotes (eAgos) or defence against invading mobile genetic elements in prokaryotes (pAgos). The majority (~60%) of pAgos identified bioinformatically are shorter (comprising only MID and PIWI domains) and are typically associated with Sir2, Mrr or TIR domain-containing proteins.

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Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion - Nature Microbiology

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Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion - Nature Microbiology

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