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Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes - Nature Cancer

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Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes - Nature Cancer

Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited success due to immune evasion mechanisms, coupled with an incomplete understanding of predictors of response. Here, from bulk and single-cell transcriptomic analyses, we identify a subset of neuroblastomas enriched for transcripts associated with immune activation and inhibition and show that these are predominantly characterized by gene expression signatures of the mesenchymal lineage state.

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Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes - Nature Cancer

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Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes - Nature Cancer

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