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Predictive validity in drug discovery: what it is, why it matters and how to improve it - Nature Reviews Drug Discovery
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Successful drug discovery is like finding oases of safety and efficacy in chemical and biological deserts. Screens in disease models, and other decision tools used in drug research and development (R&D), point towards oases when they score therapeutic candidates in a way that correlates with clinical utility in humans. Otherwise, they probably lead in the wrong direction.
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