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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates - Nature Microbiology

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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates - Nature Microbiology

Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here we describe the discovery of a series of benzoxaborole compounds with nanomolar activity against extra- and intracellular stages of T. cruzi.

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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates - Nature Microbiology

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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates - Nature Microbiology

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