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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 - Nature

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 - Nature

RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex that assembles de novo on each pre-mRNA intron through an ordered assembly of intermediate complexes1,2. Spliceosome activation is a major control step that requires substantial protein and RNA rearrangements leading to a catalytically active complex1–5.

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 - Nature

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 - Nature

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