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Failure of human rhombic lip differentiation underlies medulloblastoma formation - Nature

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Failure of human rhombic lip differentiation underlies medulloblastoma formation - Nature

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10.

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Failure of human rhombic lip differentiation underlies medulloblastoma formation - Nature

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Failure of human rhombic lip differentiation underlies medulloblastoma formation - Nature

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