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Genetic instability from a single S phase after whole-genome duplication - Nature

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Genetic instability from a single S phase after whole-genome duplication - Nature

Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications—doublings of the entire complement of chromosomes—are linked to genetic instability and frequently found in human cancers1–3. It has been established that whole-genome duplications fuel chromosome instability through abnormal mitosis4–8; however, the immediate consequences of tetraploidy in the first interphase are not known.

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Genetic instability from a single S phase after whole-genome duplication - Nature

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Genetic instability from a single S phase after whole-genome duplication - Nature

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