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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism - Nature Microbiology

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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism - Nature Microbiology

Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells remains unclear. Here we show that anti-cancer fluoropyrimidine drugs inhibit the growth of gut bacterial strains from 6 phyla. In both Escherichia coli and mammalian cells, fluoropyrimidines disrupt pyrimidine metabolism.

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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism - Nature Microbiology

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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism - Nature Microbiology

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