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Brain-restricted mTOR inhibition with binary pharmacology - Nature

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Brain-restricted mTOR inhibition with binary pharmacology - Nature

On-target–off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates1,2. In diseases of the central nervous system, drugs with brain-restricted pharmacology are highly desirable. Here we report a strategy to achieve inhibition of mammalian target of rapamycin (mTOR) while sparing mTOR activity elsewhere through the use of the brain-permeable mTOR inhibitor RapaLink-1 and the brain-impermeable FKBP12 ligand RapaBlock.

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Brain-restricted mTOR inhibition with binary pharmacology - Nature

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Brain-restricted mTOR inhibition with binary pharmacology - Nature

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