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Cohesin-mediated loop anchors confine the locations of human replication origins - Nature

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Cohesin-mediated loop anchors confine the locations of human replication origins - Nature

DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability1,2. At present, it is unknown how the locations of replication origins are determined in the human genome. Here we dissect the role of topologically associating domains (TADs)3–6, subTADs7 and loops8 in the positioning of replication initiation zones (IZs). We stratify TADs and subTADs by the presence of corner-dots indicative of loops and the orientation of CTCF motifs.

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Cohesin-mediated loop anchors confine the locations of human replication origins - Nature

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Cohesin-mediated loop anchors confine the locations of human replication origins - Nature

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