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Aneuploidy in mammalian oocytes and the impact of maternal ageing - Nature Reviews Molecular Cell Biology

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Aneuploidy in mammalian oocytes and the impact of maternal ageing - Nature Reviews Molecular Cell Biology

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo. However, human eggs frequently contain an incorrect number of chromosomes — a condition termed aneuploidy, which is much more prevalent in eggs than in either sperm or in most somatic cells. In turn, aneuploidy in eggs is a leading cause of infertility, miscarriage and congenital syndromes.

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Aneuploidy in mammalian oocytes and the impact of maternal ageing - Nature Reviews Molecular Cell Biology

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Aneuploidy in mammalian oocytes and the impact of maternal ageing - Nature Reviews Molecular Cell Biology

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