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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility - Nature Genetics

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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility - Nature Genetics

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls.

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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility - Nature Genetics

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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility - Nature Genetics

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