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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy - Nature Aging

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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy - Nature Aging

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief pulse of the drug in early adulthood in female Drosophila and mice. In Drosophila, a brief, early rapamycin treatment of adults extended lifespan and attenuated age-related decline in the intestine to the same degree as lifelong dosing.

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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy - Nature Aging

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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy - Nature Aging

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