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Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1 - Scientific Reports

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Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1 - Scientific Reports

Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing recognition of heme as a non-genomic modulator of ion channel functions. Here, we show that intracellular free heme and hemin modulate human ether à go-go (hEAG1, Kv10.1) voltage-gated potassium channels.

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Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1 - Scientific Reports

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Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1 - Scientific Reports

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