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Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infections - Scientific Reports

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Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infections - Scientific Reports

SARS-CoV-2 is notable for its extremely high level of viral replication in respiratory epithelial cells, relative to other cell types. This may partially explain the high transmissibility and rapid global dissemination observed during the COVID-19 pandemic. Polymerase chain reaction (PCR) cycle threshold (Ct) number has been widely used as a proxy for viral load based on the inverse relationship between Ct number and amplifiable genome copies present in a sample.

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Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infections - Scientific Reports

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Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infections - Scientific Reports

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