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Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival - Scientific Reports

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Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival - Scientific Reports

SARM1 is a central executioner of programmed axon death, and this role requires intrinsic NAD(P)ase or related enzyme activity. A complete absence of SARM1 robustly blocks axon degeneration in mice, but even a partial depletion confers meaningful protection. Since axon loss contributes substantially to the onset and progression of multiple neurodegenerative disorders, lower inherent SARM1 activity is expected to reduce disease susceptibility in some situations.

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Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival - Scientific Reports

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Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival - Scientific Reports

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