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Multitier mechanics control stromal adaptations in the swelling lymph node - Nature Immunology

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Multitier mechanics control stromal adaptations in the swelling lymph node - Nature Immunology

Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale.

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Multitier mechanics control stromal adaptations in the swelling lymph node - Nature Immunology

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Multitier mechanics control stromal adaptations in the swelling lymph node - Nature Immunology

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