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Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation dose - Scientific Reports

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Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation dose - Scientific Reports

In the search for biological markers after a large-scale exposure of the human population to radiation, gene expression is a sensitive endpoint easily translatable to in-field high throughput applications. Primarily, the ex-vivo irradiated healthy human blood model has been used to generate available gene expression datasets. This model has limitations i.e., lack of signaling from other irradiated tissues and deterioration of blood cells cultures over time.

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Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation dose - Scientific Reports

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Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation dose - Scientific Reports

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