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Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations - Nature Metabolism

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Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations - Nature Metabolism

Adult white adipose tissue (WAT) harbors distinct mesenchymal stromal cell subpopulations that differentially affect WAT function and plasticity. Here we unveil the cellular landscape of the perinatal epididymal WAT primordium using single-cell transcriptomics in male mice. We reveal that adipocyte precursor cells and fibro-inflammatory progenitors (FIPs) emerge as functionally distinct PDGFRβ+ subpopulations within the epididymal WAT anlagen prior to adipocyte accrual.

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Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations - Nature Metabolism

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Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations - Nature Metabolism

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