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Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses - Nature Communications

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Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses - Nature Communications

G protein-coupled receptors (GPCRs) regulate processes ranging from immune responses to neuronal signaling. However, ligands for many GPCRs remain unknown, suffer from off-target effects or have poor bioavailability. Additionally, dissecting cell type-specific responses is challenging when the same GPCR is expressed on different cells within a tissue. Here, we overcome these limitations by engineering DREADD-based GPCR chimeras that bind clozapine-N-oxide and mimic a GPCR-of-interest.

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Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses - Nature Communications

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Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses - Nature Communications

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