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Diverse mutational landscapes in human lymphocytes - Nature

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Diverse mutational landscapes in human lymphocytes - Nature

The lymphocyte genome is prone to many threats, including programmed mutation during differentiation1, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of single-cell lymphocyte cultures, we sequenced whole genomes from 717 normal naive and memory B and T cells and haematopoietic stem cells.

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Diverse mutational landscapes in human lymphocytes - Nature

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Diverse mutational landscapes in human lymphocytes - Nature

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