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Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease - Scientific Reports

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Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease - Scientific Reports

Accumulation of waste in cortical tissue and glymphatic waste clearance via extracellular voids partly drives the sleep-wake cycle and modeling has reproduced much of its dynamics. Here, new modeling incorporates higher void volume and clearance in sleep, multiple waste compounds, and clearance obstruction by waste. This model reproduces normal sleep-wake cycles, sleep deprivation effects, and performance decreases under chronic sleep restriction (CSR).

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Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease - Scientific Reports

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Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease - Scientific Reports

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