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Cyclic nucleotide-induced helical structure activates a TIR immune effector - Nature

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Cyclic nucleotide-induced helical structure activates a TIR immune effector - Nature

Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS–STING innate immunity pathway1, which originated in bacteria2.

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Cyclic nucleotide-induced helical structure activates a TIR immune effector - Nature

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Cyclic nucleotide-induced helical structure activates a TIR immune effector - Nature

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