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Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts - Scientific Reports

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Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts - Scientific Reports

Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix (ECM) resulting in fibrosis. Fibrotic ECM has altered mechanical and architectural properties, but the feedback onto FAPs of stiffness or ECM properties is largely unknown.

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Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts - Scientific Reports

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Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts - Scientific Reports

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