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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila - Nature

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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila - Nature

Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple nutrients, including the essential amino acid leucine1. Recent work in cultured mammalian cells established the Sestrins as leucine-binding proteins that inhibit mTORC1 signalling during leucine deprivation2,3, but their role in the organismal response to dietary leucine remains elusive. Here we

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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila - Nature

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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila - Nature

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