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Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods - Scientific Reports

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Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods - Scientific Reports

Metronidazole in aqueous solution is sensitive to light and UV irradiation, leading to the formation of N-(2-hydroxyethyl)-5-methyl-l,2,4-oxadiazole-3-carboxamide. This is revealed here by liquid chromatography with tandem photo diode array detection and mass spectrometry (LC-PDA-MS) and further verified by comparison with the corresponding reference substance and proton nuclear magnetic resonance (1H-NMR).

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Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods - Scientific Reports

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Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods - Scientific Reports

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