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Action suppression reveals opponent parallel control via striatal circuits - Nature

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Action suppression reveals opponent parallel control via striatal circuits - Nature

The direct and indirect pathways of the basal ganglia are classically thought to promote and suppress action, respectively1. However, the observed co-activation of striatal direct and indirect medium spiny neurons2 (dMSNs and iMSNs, respectively) has challenged this view. Here we study these circuits in mice performing an interval categorization task that requires a series of self-initiated and cued actions and, critically, a sustained period of dynamic action suppression.

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Action suppression reveals opponent parallel control via striatal circuits - Nature

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Action suppression reveals opponent parallel control via striatal circuits - Nature

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