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A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization - Communications Biology

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A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization - Communications Biology

Microglia in hemorrhagic stroke contribute to both acute-phase exacerbation and late-phase attenuation of injury. Here, by using the mouse model, we reported that the shift in polarization of microglia from M1 to M2 phenotype could be altered by a past 'mini' stroke, resulting in better neurological function recovery, faster attenuation of lesion volume, and better survival. In mice with a previous stroke, M2 predominance appeared markedly in advance compared to mice without a previous stroke.

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A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization - Communications Biology

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A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization - Communications Biology

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