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Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics? - Modern Pathology

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Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics? - Modern Pathology

Rearrangements of the transcription factors FOS and FOSB have recently been identified as the genetic driver event underlying osteoid osteoma and osteoblastoma. Nuclear overexpression of FOS and FOSB have since then emerged as a reliable surrogate marker despite limitations in specificity and sensitivity. Indeed, osteosarcoma can infrequently show nuclear FOS expression and a small fraction of osteoblastomas seem to arise independent of FOS/FOSB rearrangements.

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Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics? - Modern Pathology

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Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics? - Modern Pathology

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