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A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia - npj Genomic Medicine

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A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia - npj Genomic Medicine

Idiopathic hypersomnia (IH) is a rare, heterogeneous sleep disorder characterized by excessive daytime sleepiness. In contrast to narcolepsy type 1, which is a well-defined type of central disorders of hypersomnolence, the etiology of IH is poorly understood. No susceptibility loci associated with IH have been clearly identified, despite the tendency for familial aggregation of IH.

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A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia - npj Genomic Medicine

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A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia - npj Genomic Medicine

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