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Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines - npj Vaccines

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Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines - npj Vaccines

The development and use of antibacterial glycoconjugate vaccines have significantly reduced the occurrence of potentially fatal childhood and adult diseases such as bacteremia, bacterial meningitis, and pneumonia. In these vaccines, the covalent linkage of bacterial glycans to carrier proteins augments the immunogenicity of saccharide antigens by triggering T cell-dependent B cell responses, leading to high-affinity antibodies and durable protection.

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Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines - npj Vaccines

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Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines - npj Vaccines

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