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ILC1s control leukemia stem cell fate and limit development of AML - Nature Immunology

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ILC1s control leukemia stem cell fate and limit development of AML - Nature Immunology

Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in mammalian tissues. However, their function in cancer is mostly undefined. Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus blocking the production of terminal myeloid blasts.

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ILC1s control leukemia stem cell fate and limit development of AML - Nature Immunology

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ILC1s control leukemia stem cell fate and limit development of AML - Nature Immunology

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