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Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain - npj Antimicrobials and Resistance
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Oral coamoxiclav and amoxicillin, for extended dose regimens of up to 100 days, have shown benefit in the treatment of Chronic Lower Back Pain (CLBP) associated with vertebral bone oedema, known as Modic type 1 changes, which may be caused by a bacterial infection, but the magnitude of clinical improvement has been variable.
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