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An engineered influenza virus to deliver antigens for lung cancer vaccination - Nature Biotechnology

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An engineered influenza virus to deliver antigens for lung cancer vaccination - Nature Biotechnology

The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by challenges in delivery of neoantigens to the tumor. Here, using the model antigen ovalbumin (OVA) in a melanoma model, we demonstrate a chimeric antigenic peptide influenza virus (CAP-Flu) system for delivery of antigenic peptides bound to influenza A virus (IAV) to the lung.

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An engineered influenza virus to deliver antigens for lung cancer vaccination - Nature Biotechnology

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An engineered influenza virus to deliver antigens for lung cancer vaccination - Nature Biotechnology

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