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Click chemistry: a transformative technology in nuclear medicine - Nature Protocols
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The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. Sharpless and Meldal worked to develop the canonical click reaction—the copper-catalyzed azide–alkyne cycloaddition—while Bertozzi opened new frontiers with the creation of the bioorthogonal strain-promoted azide–alkyne cycloaddition.
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