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Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes - Nature Medicine

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Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes - Nature Medicine

Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11–93 years, we found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter.

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Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes - Nature Medicine

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Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes - Nature Medicine

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