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Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions - Scientific Reports

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$Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions - Scientific Reports$

Non-invasive prenatal testing (NIPT) to detect fetal aneuploidy by sequencing the cell-free DNA (cfDNA) in maternal plasma is being broadly adopted. To detect fetal aneuploidies from maternal plasma, where fetal DNA is mixed with far-larger amounts of maternal DNA, NIPT requires a minimum fraction of the circulating cfDNA to be of placental origin, a level which is usually attained beginning at 10 weeks gestational age.

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Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions - Scientific Reports

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Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions - Scientific Reports

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